METFORMIN AND MALIGNANT TUMORS: NOT OVER THE HILL

Metformin and Malignant Tumors: Not Over the Hill

Weiling Leng,1,* Juan Jiang,2,* Bing Chen,1 Qinan Wu3 1Endocrinology Department, The First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China; 2Endocrinology and Nephrology Department, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Ca

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Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversity

Abstract Background Understanding human genetic influences on the gut microbiota helps elucidate the mechanisms by which genetics may influence health outcomes.Typical microbiome genome-wide association studies (GWAS) marginally assess the association between individual genetic variants and individual microbial taxa.We propose a novel approach, the

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Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2

Abstract Background Recent evidence suggests that several human cancers are capable of uncoupling of mitochondrial ATP generation in the presence of intact tricarboxylic acid (TCA) enzymes.The goal of the current study was to test the hypothesis that ketone bodies Satchel can inhibit cell growth in aggressive cancers and that expression of uncoupli

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